Cleopatra is the final boss of Double Dragon 3: The Rosetta Stone and the Famicom version of Double Dragon III: The Sacred Stones. She is found in the inner chamber of her pyramid, where she guards her secret treasure from beyond her grave. In her first form she appears as a Mummy, and after being defeated her spirit rises from her dead body and warps everyone to another dimension for the final fight. She constantly teleports around the room, attacking with various projectiles and telekinetically pushing the player. Upon being defeated, her spirit vanishes and her treasure is revealed. In the arcade game, she screams and disappears when defeated, and her gown falls to the floor in a heap.

In the NES game, Cleopatra is replaced by Princess Noiram, who is revealed to be Marian possessed by an evil spirit. However, she uses the same sprites that are used for Cleopatra in the Famicom game.